These images are from a 70 year-old man who began
experiencing difficulty with memory about 9 months prior to imaging.
He had a
history of atrial fibrillation and was taking warfarin. He had become lost on
several occasions, and had difficulty orienting himself in unfamiliar
circumstances.
His performance on a standardized assessment of general
cognitive status(the "mini mental status examination", or MMSE) was
normal.
MR images showed globally widened hemispheric sulci, which is more
prominent in parietal lobes.
Regional cerebral metabolism is markedly abnormal,
with hypometabolism in anterior temporal and posterior parietal regions.
These
changes are bilateral, but the right hemisphere is slightly more affected than
the left, and the posterior cingulate is relatively spared.
